PDRN is the abbreviation of the full English name of "polydeoxyribonucleotide", which is a DNA fragment extracted from the testicular tissue cells of salmon (also known as salmon). This substance is basically consistent with the base composition of human DNA.
Further study the mechanism of action and potential application value of PDRN; finally, based on the multiple pharmacological properties of PDRN itself, as well as its low immunogenicity and non-systemic toxicity, PDRN will definitely be a good choice for future tissue damage repair drugs.
In terms of skin care, PDRN shows excellent anti-inflammatory repair ability, can effectively improve red blood streaks, dull skin color and other problems, and promote collagen synthesis to achieve skin rejuvenation
PDRN originated from an ancient fishing village in Europe, where a secret method passed down from generation to generation is circulated. Fishermen found that applying salmon semen to wounds can promote rapid healing of wounds. This magical phenomenon has aroused great interest among scientists.
After in-depth research, scientists successfully extracted this magical ingredient from salmon semen and named it PDRN. This discovery not only brought a revolutionary breakthrough in the field of medical beauty, but also provided a new choice for people who pursue beauty and health.
In the early twentieth century, Italian scientists successfully extracted PDRN from salmon germ cells and found that it was very similar to human PDRN. Since the base similarity between salmon DNA and human DNA is as high as 98%, PDRN is non-immunogenic, safe and non-toxic in the human body. This important discovery has brought new hope to the medical field.
In 2001, salmon PDRN was first used for wound healing after transplantation and achieved remarkable results. It can actively promote the repair process of the donor site of autologous skin transplantation and show extremely high safety. In addition, PDRN was also widely used in medical fields such as wound healing and bone and soft tissue regeneration in the early days.
As the beauty industry shifts from an "ingredients first" to an "efficacy first" mindset, the industry's efforts to develop and utilize active compounds have also gone to a higher level - in addition to listing novel ingredients on packaging and promotion, the efficacy is based on a deep understanding and utilization of biological mechanisms.
Under this trend, it seems natural that PDRN (polydeoxyribonucleotide) has become a "newcomer" in skin care. This bioactive substance derived from salmon spermatocyst cell DNA has recently attracted much attention in the international market.
Exploding Topics reports that its related searches have increased by 200% in recent years, largely due to its unique cell signaling pathway regulation properties and scientifically proven beauty benefits.
PDRN consists of DNA fragments with molecular weights between 50 and 1500kDa. Its efficacy is mediated by activating adenosine A2A receptors and rescue pathways, which can promote collagen synthesis, soft tissue regeneration and skin recovery, and can also improve pigmentation.
Preliminary studies have found that PDRN has the function of promoting collagen synthesis, inhibiting MMPs, elastase and other activities, and has the function of reconstructing ECM and delaying skin aging.
In addition, PDRN also has antioxidant and photoprotective functions. Studies have shown that oxidative stress and long-term exposure to ultraviolet rays are important factors leading to skin aging.
PDRN has a certain preventive and therapeutic effect on skin photoaging, and its mechanism may be achieved through antioxidant and photoprotection. PDRN can also improve the elasticity and smoothness of the skin.
Preliminary studies have found that PDRN can inhibit melanin production, inhibit tyrosinase activity, and reduce the expression of related transcription factors (MITF) and TRP-1 (tyrosinase-related protein-1).Clinical studies have shown that PDRN has a good therapeutic effect on the treatment of melasma and photoaging.
Medical cosmetology is generally divided into two types: traumatic and non-traumatic. Laser is the most widely used minimally invasive plastic surgery in clinical practice. Its main purpose is to repair scars and has obvious "skin rejuvenation" effects.
Trauma is easy to occur after fractional laser treatment and should be treated in time. Adverse factors such as wound depth, severity of inflammation, presence or absence of diabetes and local ischemia will affect wound healing.
Some scholars used rat models to study the significant improvement effect of PDRN on trauma treated with fractional laser. Compared with the control group, the wound healing time of the PDRN treatment group was shorter. Pathological results showed that the PDRN group had greater granulation tissue thickening than the control group.
Immunohistochemical staining found that the expression of VEGF and PECAM-1/CD31 increased significantly after administration.
Studies have shown that the early application of PDRN after surgery can prevent the formation of postoperative scars. Its mechanism of action is to reduce inflammation and accelerate wound healing.
PDRN can inhibit inflammatory response, promote microcirculation, and promote hair growth to a certain extent. The research team's preliminary study found that 1927 nm fractional laser combined with platelet-rich plasma (PRP) and PDRN technology has a good effect on androgenic alopecia.
Percutaneous microscopy showed that PDRN can not only increase hair, but also significantly reduce scalp erythema and other inflammatory reactions.
Allergic skin, like rosacea, has skin barrier damage and neuroinflammation. However, PDRN has obvious anti-inflammatory and repair effects. For sensitive skin, rosacea has a certain effect.
The overall effect of using PDRN to treat sensitive skin and rosacea is very good. PDRN has a good effect on rosacea, neither inducing nor aggravating the immune response of the skin, but also increasing the moisture content of the skin, increasing the thickness of the skin, and improving sensitivity.
XIRAN COSMETICS has developed a green extraction process for obtaining PDRN from plants (such as rice), making the production process of PDRN animal-friendly and vegan.
Compared with salmon PDRN, green PDRN from rice has a smaller molecular weight and similar efficacy, and is even better than salmon PDRN in promoting wound healing.
RICE PDRN promotes stable connection of the true epidermal junction layer DEJ by enhancing the expression of Laminin 5 and type 17 collagen °.
Laminin 5: Laminin 5, which is secreted by keratinocytes and can stabilize the connection between the epidermis and the dermis; it can also accelerate the assembly of the basement membrane and enhance the repair of damaged skin.
Type 17 collagen: It strengthens DEJ by binding to type 4 collagen.
Occludin: Occludin, a tightly connected membrane protein, regulates the integrity of the skin barrier. RICE PDRN accelerates the synthesis of occludin and repairs the skin barrier damaged by UVB.
nhibits the transfer of melanosomes
Inhibits melanin formation
MTNR1A (Melatonin Receptor 1A): Melatonin receptor of fibroblasts
1A is essential in regulating sleep cycles;
It maintains the shape of the skin through a 24-hour cycle of recovery process-this becomes the circadian rhythm, in which DNA repair, barrier permeability, cell proliferation and skin penetration usually occur at night.
Plant-derived RICE PDRN is a new attempt by XIRAN COSMETICS to apply medical beauty ingredients to the field of beauty.
The green extraction process is not only more in line with the trends of EGS, pure aesthetics, and animal-friendly, but also allows consumers to use PDRN in a "non-invasive" way, which is more convenient and safe!
If you want to learn more about PDRN or want to develop PDRN skin care products, please contact us. We have a professional team to research and develop.
